Among patients with leiomyosarcoma, a combination of doxorubicin and trabectedin with prolonged trabectedin maintenance therapy led to longer overall survival than doxorubicin alone (median, 33 vs. 24 months).
The Supreme Court’s decision in Loper Bright Enterprises v. Raimondo could open the door to more, and broader, challenges to actions taken by health agencies.
In June 2024, the Supreme Court issued an order halting implementation of a regulation intended to limit the interstate spread of ozone-forming emissions. The decision could endanger human health.
This video shows how the Northern Navajo Medical Center is working to improve continuity of care to build patients’ trust and better address their complex medical and social needs.
A 54-year-old man presented with a 2-month history of worsening shortness of breath and cough. A chest radiograph showed innumerable rounded opacities in the lungs, and a CT scan showed “cannonball” pulmonary lesions.
In a 57-year-old man with chest pain, an ECG obtained by EMS showed widespread ST-segment depressions. At the hospital, left main coronary-artery stenosis was seen on angiography (shown in a video).
Original Research
In adults with migraine and previous preventive treatment failures, a single infusion of a monoclonal antibody to pituitary adenylate cyclase–activating polypeptide led to fewer migraine days per month than placebo over the next 4 weeks.
In this trial involving patients with acute ischemic stroke treated with thrombolysis within 3 hours after symptom onset, the use of adjunctive intravenous argatroban or eptifibatide did not improve 90-day poststroke outcomes.
Among patients with a previous myocardial infarction, interruption of long-term beta-blocker therapy was not found to be noninferior to continuation with respect to adverse events at a median of 3 years.
In June 2019, a man presented with fever and severe illness in Inner Mongolia. An orthonairovirus was identified as a potential cause. This agent was identified in an additional 16 patients and was found in ticks.
A woman with aggressive refractory systemic lupus erythematosus was treated with a short course of the bispecific antibody teclistamab (anti–B-cell maturation antigen and anti-CD3) and had a drug-free complete remission.
In four patients with severe autoimmune disease, teclistimab, a bispecific antibody to B-cell maturation antigen and CD3, resulted in autoantibody reduction and clinical response after short-term follow-up.
Clinical Practice and Review
For 100 years, the Journal’s publication of the Case Records of the Massachusetts General Hospital has helped to guide medical practice and build a global community of clinicians.
A 9-year-old girl presented with a 7-day history of a lesion on the left cheek and a 4-day history of fever. Treatment for possible impetigo had not alleviated the symptoms.
Pancreatic cysts are often found incidentally on imaging tests for other indications. Imaging, symptom assessment, and laboratory tests can help distinguish benign cysts from those associated with a risk of malignant transformation.
One hundred years ago, a 24-year-old man was admitted to the hospital because of fever, cough, and shortness of breath. The patient died on the fourth hospital day. What is the diagnosis?
With health care workforces in the United States and Europe shrinking at unsustainable rates, it’s vital to understand the drivers of moral injury so that solutions can be developed.
When a patient takes offense at her questions about possible intimate partner violence, a physician convinces herself she must set aside her intuitions to retain the patient’s trust.
