In this randomized, controlled trial, persons with early syphilis received a single treatment or three treatments with benzathine penicillin G at a dose of 2.4 million units. No benefit was seen with the additional doses.
A phase 2 trial of once-monthly maridebart cafraglutide, a peptide–antibody conjugate, showed substantial weight reduction in participants with obesity with or without type 2 diabetes.
Corporatization represents a deal between medical organizations and investors and presumably benefits those entities. But the key question for society is whether it benefits patients and payers.
This video demonstrates abdominal paracentesis with static ultrasound guidance, a technique that may be performed as either a diagnostic or a therapeutic procedure.
This trial used email nudges to adult members of Kaiser Permanente health plans in Northern California and in the U.S. Mid-Atlantic to encourage uptake of influenza vaccination. Two rounds of electronic nudges emphasizing the cardiovascular benefits of vaccination versus usual care were sent to over 3.6 million people enrolled in the health plan. Although the trial was technically successful in that the messages went out across the care system, there was no difference among the various groups in vaccine uptake.
The Nova food-classification system has advanced efforts to address modern diets of highly processed foods. But it’s unclear whether it can be codified at a national level to support public health.
A 75-year-old man presented with a 3-week history of fatigue and palpitations. Bulging of the biceps during elbow flexion was noted. ECG showed low-voltage QRS complexes, and echocardiography showed left ventricular hypertrophy.
This study demonstrates that smartphone video–based biomechanical analysis can accurately replicate traditional timed function tests — commonly used to diagnose and assess movement-related conditions such as neuromuscular disorders — while also capturing disease-specific movement patterns that timed function tests fail to detect.
Original Research
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. This phase 1–2 study supports the hypothesis that zimislecel can restore physiologic islet function and thus treat persons with type 1 diabetes.
A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells.
In patients with heparin-induced thrombocytopenia, pathogenic antibodies were found to be monoclonal, which challenges previous views of HIT as a polyclonal disorder and suggests new avenues for diagnosis and treatment.
The authors describe the science behind two studies that examined different cellular strategies to treat type 1 diabetes.
A woman in her 70s died of an acute febrile illness with severe myocardial dysfunction. A novel thogotovirus, the Oz virus, was identified in the myocardial tissue.
After coronary bypass for acute coronary syndrome, adding ticagrelor to aspirin did not reduce cardiovascular events but increased major bleeding at 1 year, as compared with aspirin alone.
In rural South Africa, home-based hypertension care — delivered by community health workers and supported by remote nurses — led to a lower mean systolic blood pressure than clinic-based care.
Clinical Practice and Review
This review describes the current management of type B aortic dissection, including medical therapy and thoracic endovascular aortic repair.
A 37-year-old woman presented with a 4-day history of pain, swelling, and bruising on the upper portion of her left knee after using a massage gun. She reported no other bruising or bleeding apart from chronic menorrhagia. What is the diagnosis?
A 54-year-old woman with infiltrating ductal carcinoma of the right breast treated with locoregional radiation presented with cough, fever, and dyspnea. CT showed fibrotic and ground-glass opacities in the irradiated area.
Many learners are more facile with the use of large language models in medicine than their supervisors are. The authors provide an approach to clinical supervision that can mitigate the perils and amplify the promise of AI.
With numbers of physician-scientists declining worldwide, China offers a case study reflecting both global barriers and scalable strategies for harmonizing clinical care and research innovation.
A 71-year-old man presented with a 2-year history of a darkening line on his left thumbnail. Also noted were a brown discoloration of the left thumbnail and hyperpigmentation of the proximal nail fold and tip of the thumb.
China has recently emerged as an important player in new drug development — a field traditionally dominated by the United States and Europe. This shift has implications for global access to new medicines.
