Among adults with pulmonary arterial hypertension at high risk for death, sotatercept reduced the risk of a composite of death from any cause, lung transplantation, or hospitalization for worsening pulmonary arterial hypertension.
In a randomized trial, pulsed field ablation was noninferior to cryoballoon ablation with respect to the incidence of a first recurrence of atrial tachyarrhythmia, as assessed by continuous rhythm monitoring.
In a randomized trial, the routine use of cerebral embolic protection during TAVI did not reduce the incidence of stroke within 72 hours or before discharge from the hospital (if discharge occurred sooner).
Among participants with type 2 diabetes and cardiovascular disease, chronic kidney disease, or both, oral semaglutide (14 mg) was associated with a lower risk of cardiovascular events than placebo after 4 years of follow-up.
Starting in January 2025, various government health datasets were removed, restored, manipulated, or not posted as planned. The consequences of these changes could be far-reaching.
Using data from 2,078,948 participants from 39 countries, researchers calculated lifetime estimates of cardiovascular disease and death from any cause according to the presence or absence of cardiovascular risk factors.
Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels.
Among older patients undergoing TAVI, dapagliflozin led to a lower incidence of a composite of death from any cause or worsening of heart failure than standard care at 1 year.
Some pharmaceutical companies have launched platforms that direct users to websites run by telehealth companies, where clinicians are available to prescribe drugs. Such arrangements have prompted concerns.
Original Research
In patients with chronic severe rhinosinusitis and nasal polyps, tezepelumab therapy led to greater reductions in polyp size and nasal congestion and less use of surgery and glucocorticoids than placebo.
In this trial, patients with type 2 diabetes had a lower incidence of major cardiovascular outcomes with a systolic blood-pressure target of less than 120 mm Hg than with a target of less than 140 mm Hg.
The selective estrogen-receptor degrader imlunestrant plus abemaciclib led to a median progression-free survival of 9.4 months among patients with ER-positive, HER2-negative breast cancer (vs. 5.5 months with imlunestrant alone).
In a trial involving 135 participants with IgG4-related disease, inebilizumab was associated with significantly lower flare risk and greater likelihood of complete remission than placebo at 1 year.
A reversible interaction between bempedoic acid and fenofibrate leading to a major, reversible decrease in HDL cholesterol levels was found in patients treated for nongenetic elevated LDL cholesterol levels.
Clinical Practice and Review
This feature about a man who had had a myocardial infarction with preserved left ventricular ejection fraction offers a case vignette accompanied by two essays, one supporting the use of beta-blockers after discharge and the other recommending no use of beta-blockers. Cast your vote.
This review discusses challenges and pitfalls in the diagnosis and management of chronic cough that is unexplained after a complete evaluation or that is refractory to treatment for identified causes.
A recent study of an mRNA vaccine in a mouse model of Clostridioides difficile infection provided proof of concept of a protective effect.
When his mother is diagnosed with what medicine calls “heart failure,” an epidemiologist identifies harmful flaws in both the term and communication with patients and families.
A 59-year-old man with a history of metabolic dysfunction–associated steatotic liver disease had an enlarging liver mass. Biopsy showed hepatocellular carcinoma. How was this case managed?
A 40-year-old man who was being treated in the ICU after inhalation of car exhaust in a suicide attempt was noted to have red urine.
A full-term baby boy was transferred to the NICU at 30 hours of age with abdominal distention and failure to pass meconium. An abdominal radiograph showed dilated loops of small intestine.
