In patients with acute ischemic stroke treated with intravenous thrombolysis, early tirofiban improved functional outcomes at 90 days. Intracranial hemorrhage was uncommon but more frequent with tirofiban.
A 3-year structured exercise program after adjuvant chemotherapy for colon cancer improved disease-free and overall survival, physical functioning, and fitness, as compared with health education alone.
As health systems confront the social, economic, and political drivers underlying worsening U.S. population health, a new Perspective series examines the extent to which the business of health care may promote or impede progress.
“Corporatization” of health care, a process predicted decades ago, now refers to the general trend throughout the industry toward higher levels of integrated control by consolidated profit-seeking enterprises.
A 57-year-old man presented with a 2-week history of worsening shortness of breath. Radiography and CT showed perihilar airspace opacities in both lungs, and bloody aliquots of fluid were obtained by bronchoalveolar lavage.
Despite the potential for drug-price negotiation to help rein in spending, several provisions in the Inflation Reduction Act may limit Medicare’s new negotiating authority for biologics.
A new report from the National Academy of Medicine proposes a research agenda to address climate-related health risks and data gaps, emphasizing equity, innovation, and interdisciplinary collaboration.
Navigating cases of potential self-neglect is complicated for older adults and for the family members, clinicians, and social and legal services professionals involved in ensuring their well-being.
Original Research
In this phase 3b, open-label, randomized, controlled trial involving adults with obesity without type 2 diabetes, tirzepatide was superior to semaglutide in reducing body weight and waist circumference.
In a phase 3 trial, the addition of neoadjuvant and adjuvant pembrolizumab to standard care improved event-free survival among participants with locally advanced head and neck cancer without affecting surgical outcomes.
Prenatal genomic sequencing revealed congenital thrombotic thrombocytopenic purpura, enabling immediate plasma therapy. The case highlights the value and ethical complexity of reporting incidental findings.
In a randomized trial involving patients at high cardiovascular risk, the cholesteryl ester transfer protein inhibitor obicetrapib reduced low-density lipoprotein cholesterol levels by 29.9% at 84 days.
A phase 2 trial of once-monthly maridebart cafraglutide, a peptide–antibody conjugate, showed substantial weight reduction in participants with obesity with or without type 2 diabetes.
Clinical Practice and Review
Forensic pathologists play key roles in many areas of public health, including mass casualty events and disease or drug epidemics, and in the justice system. They also act as bridges to families of deceased persons and society.
A 64-year-old man presented with a 5-month history of a painful ulcer of the lateral left ankle. Recently, he had noticed malodorous secretions, increased erythema and edema, and worsening pain. What is the diagnosis?
A 23-year-old man presented with a 2-day history of painful swallowing and hoarseness. The symptoms had started immediately after he had inhaled nitrous oxide through his mouth from a hand-held canister for recreation.
Grieving her father after his sudden death, a resident finds herself paralyzed by fear that her lack of knowledge will cause harm to patients.
Discontinuity negatively affects patients, learners, and health care systems. Changes that create continuity could improve both patient outcomes and the learning environment for medical trainees.
